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Mutation Information
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Mutation Site
|
N238S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
Y1855;
DQ448619.1 |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
22138714
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2012 |
|
Journal
|
Antiviral research |
|
Title
|
Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B. |
|
Author
|
Zhong Y,Lv J,Li J,Xing X,Zhu H,Su H,Chen L,Zhou X |
|
Evidence
|
Among 1865 enrolled HBV infected patients, 8.8% (165/1865) showed mutations in the rtN238 locus (143 males/22 females, 91 treatment-naive, 42 ADV-treated, 16 LAM-treated and 16 ADV+LAM-treated), namely 86% rtN238H (142/165), 5.5% rtN238S (9/165), 5.5% rtN238T (9/165) and 3% rtN238D (5/165).
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HBV Mutation Detail Information