HBV Mutation Detail Information

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Mutation Information

Mutation Site	Y124H
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	B;C
Country	China;South Korea

Literature Information

PubMed PMID	29713126
Published Year	2018
Journal	World journal of gastroenterology
Title	Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
Author	Choi YM,Lee SY,Kim BJ
Evidence	Our literature based pooled incidence data showed that several putative or pretreatment mutations, including rtI91L, mutations in 6 positions of A-B interdomain (rtY124H, rtY126C/R/H, rtT128I/N, rtD134E/N, rtN139D/E/H/K/Q and rtW153Q/R/E), rtF221Y and rtI224V, were encountered with high frequency from the treatment naïve patients;Other amino acid substitutions, which were detected before treatment, but for which the association between their occurrence and drug resistance has not been evaluated, are defined as pretreatment mutations, these include rtT38A, rtY124H, rtD134E/N, rtN139K/H, rtI224V, and rtR242A (Category 4) (Table 1)[21,38].

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation