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Mutation Information
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Mutation Site
|
L269I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
C2 |
|
Relevant Drug
|
lamivudine (LAM);clevudine (CLV);entecavir (ETV);adefovir (ADV);tenofovir (TDF) |
|
Country
|
South Korea |
Literature Information
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PubMed PMID
|
26322642
|
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Published Year
|
2015 |
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Journal
|
PloS one |
|
Title
|
Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance. |
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Author
|
Ahn SH,Kim DH,Lee AR,Kim BK,Park YK,Park ES,Ahn SH,Shin GC,Park S,Kang HS,Rhee JK,Yang SI,Chong Y,Kim KH |
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Evidence
|
The rtL269I substitution conferred 2- to 7-fold higher replication capacity in the wild-type (WT) or YMDD mutation backbone, regardless of drug treatment.
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HBV Mutation Detail Information