HBV Mutation Detail Information

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Mutation Information
Mutation Site T128I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Genotype/Subtype A
Viral Reference X02763.1
Relevant Drug lamivudine (LAM)
Country South Africa
Literature Information
PubMed PMID 31248149
Clinical information Yes
Disease HBV infection
Published Year 2019
Journal Viruses
Title Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis.
Author Baxter C,Ngcapu S,Blackard JT,Powell EA,Penton PK,Abdool Karim SS
Evidence Although the frequency of amino acid substitutions were not significantly different, a total of 16 amino acid substitutions in the polymerase domain occurred only in tenofovir-experienced isolates compared to tenofovir-naive isolates, including S117Y, S117C, I121N, T128I, M129L, R138K, R138E, L140P, V142A, I163V, L217R, N238H, R242K, K270R, V278I, and R280S. Positions R110G, Y126H, T128S, W153R, L220I, T225I, P237H, T259S and H271C were highly polymorphic in tenofovir-naive compared to tenofovir-experienced isolates. No mutations known to cause tenofovir resistance (L180M, A181I/V, A194T, M204V/I, V214A, Q215S, N236T) or lamuvudine (3TC) resistance (L80V/I, I169T, V173L, L180M, A181T, T184S, M204V/I/S, Q215S) were observed. Absence of these mutations was also confirmed using the INNO-LiPA HBV DR v3 commercial kit (Innogenetics, N.V., Gent, Belgium)

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation