HBV Mutation Detail Information

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Mutation Information

Mutation Site	Y221L
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	A;D
Country	America

Literature Information

PubMed PMID	28322924
Disease	Chronic hepatitis B
Published Year	2017
Journal	Antiviral research
Title	Evolutionary trends of resistance mutational patterns of HBV reverse transcriptase over years (2002-2012) of different treatment regimens: The legacy of lamivudine/adefovir combination treatment.
Author	Vincenti D,Piselli P,Solmone M,D'Offizi G,Capobianchi MR,Menzo S
Evidence	Furthermore, the study allows a better understanding of how viral genotype (A vs D) conditions specific mutational pathways to resistance against lamivudine and entecavir, and demonstrates that the use of adefovir in lamivudine experienced patients is associated to peculiar mutational patterns, in particular A181V + F/Y221L.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation