|
Mutation Information
|
Mutation Site
|
F151L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
26825915
|
|
Disease
|
HBV infection
|
|
Published Year
|
2016 |
|
Journal
|
Medicine |
|
Title
|
Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study. |
|
Author
|
Zhang XX,Li MR,Cao Y,Zhang RW,Zhang Y,Li F,Xi HL,Xu XY |
|
Evidence
|
In addition to the common substitutions, unknown amino acid substitutions, such as rtL145 M/S, rtF151Y/L, rtR153Q, rtI224 V, rtN248H, rtS223A, rtS256C, need to be further verified. NAr substitutions are observed at frequencies of 0.10% to 6.7% before therapy.
|
|
|
HBV Mutation Detail Information