|
Mutation Information
|
Mutation Site
|
I233V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A2 |
|
Relevant Drug
|
adefovir (ADV) |
Literature Information
|
PubMed PMID
|
21696601
|
|
Disease
|
HBV infection
|
|
Published Year
|
2011 |
|
Journal
|
BMC infectious diseases |
|
Title
|
Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations. |
|
Author
|
Cassino L,Benetti S,Fay F,Tanno H,Quarleri J |
|
Evidence
|
When this therapy was interrupted for 6 months, quasispecies composition almost exclusively consisted of wild-type pol nucleotide sequences, except for a minor contribution (< 10%) showing the adefovir resistance-associated mutation I233V.
|
|
|
HBV Mutation Detail Information