|
Mutation Information
|
Mutation Site
|
I266G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
X72702;
AY796031;
AY741796;
AY661792;
AY796030;
AY721605 |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Turkey |
Literature Information
|
PubMed PMID
|
24630522
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Diagnostic microbiology and infectious disease |
|
Title
|
Analysis of potential antiviral resistance mutation profiles within the HBV reverse transcriptase in untreated chronic hepatitis B patients using an ultra-deep pyrosequencing method. |
|
Author
|
Ciftci S,Keskin F,Cakiris A,Akyuz F,Pinarbasi B,Abaci N,Dincer E,Badur S,Kaymakoglu S,Ustek D |
|
Evidence
|
However, NAr mutations found in 6 isolates (37.5%) involved 7 positions including rtL91I, rtT128I, rtQ215P, rtF221Y, rtN238D, rtC256S, and rtI266G. Substitutions at 3 NAr mutation sites (rtT128I, rtN238D, and rtC256S) were detected in 3 unresponsive patients developing drug resistance after NA treatment.
|
|
|
HBV Mutation Detail Information