HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204I+rt.L180M;rt.M204I+rt.L180M
Relevant Drug	lamivudine (LAM);entecavir (ETV);telbivudine (LDT)
Country	Turkey

Literature Information

PubMed PMID	20382061
Disease	Chronic hepatitis B
Published Year	2010
Journal	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Title	Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B.
Author	Sayan M,Sentürk O,Akhan SÇ,Hülagü S,Cekmen MB
Evidence	Interestingly, the treatment-naive patients had preexisting drug resistance mutations related to lamivudine (rtL180M+rtM204I), adefovir (rtA181V, rtQ215S, rtI233V), entecavir (intermediate susceptibility with rtL180M+rtM204IHBV variant), telbivudine (rtL180M+rtM204I), and tenofovir (rtA194T).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation