HBV Mutation Detail Information

> H234Q Search Result


Mutation Information
Mutation Site H234Q
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug adefovir (ADV)
Literature Information
PubMed PMID 12829991
Disease Chronic hepatitis B
Published Year 2003
Journal Hepatology (Baltimore, Md.)
Title Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B.
Author Westland CE,Yang H,Delaney WE 4th,Gibbs CS,Miller MD,Wulfsohn M,Fry J,Brosgart CL,Xiong S,437 and 438 Study Teams.
Evidence Four substitutions (rtS119A, rtH133L, rtV214A, and rtH234Q) developed once each at conserved sites in HBV polymerase in 4 ADV-treated patients.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation