Mutation Information
Mutation Site
|
H234Q |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Relevant Drug
|
adefovir (ADV) |
Literature Information
PubMed PMID
|
12829991
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2003 |
Journal
|
Hepatology (Baltimore, Md.) |
Title
|
Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B. |
Author
|
Westland CE,Yang H,Delaney WE 4th,Gibbs CS,Miller MD,Wulfsohn M,Fry J,Brosgart CL,Xiong S,437 and 438 Study Teams. |
Evidence
|
Four substitutions (rtS119A, rtH133L, rtV214A, and rtH234Q) developed once each at conserved sites in HBV polymerase in 4 ADV-treated patients.
|
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