HBV Mutation Detail Information

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Mutation Information
Mutation Site M204I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.M204I+rt.L180M+rt.L180L
Genotype/Subtype A
Viral Reference X02763
Country Asia‐Pacific;Europe
Literature Information
PubMed PMID 32579776
Disease Chronic hepatitis B
Published Year 2020
Journal Journal of viral hepatitis
Title Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy.
Author Verbinnen T,Hodari M,Talloen W,Berke JM,Blue D,Yogaratnam J,Vandenbossche J,Shukla U,De Meyer S,Lenz O
Evidence One 75 mg JNJ‐6379‐treated patient (HBeAg‐positive, GT‐D) carried the lamivudine‐resistant mutations L180L/M + M204I as baseline polymorphisms and showed a pronounced HBV DNA decline of 3.36 log10 IU/mL at the end of treatment (patient #14, Figure 2B).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation