Mutation Information
Mutation Site
|
M204I |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.M204I+rt.L180M+rt.L180L |
Genotype/Subtype
|
A |
Viral Reference
|
X02763
|
Country
|
Asia‐Pacific;Europe |
Literature Information
PubMed PMID
|
32579776
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2020 |
Journal
|
Journal of viral hepatitis |
Title
|
Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy. |
Author
|
Verbinnen T,Hodari M,Talloen W,Berke JM,Blue D,Yogaratnam J,Vandenbossche J,Shukla U,De Meyer S,Lenz O |
Evidence
|
One 75 mg JNJ‐6379‐treated patient (HBeAg‐positive, GT‐D) carried the lamivudine‐resistant mutations L180L/M + M204I as baseline polymorphisms and showed a pronounced HBV DNA decline of 3.36 log10 IU/mL at the end of treatment (patient #14, Figure 2B).
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