HBV Mutation Detail Information

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Mutation Information
Mutation Site G741C
Mutation Type Nucleotide level
Gene/Protein/Region Type RT
Combined Mutation rt.M204I+rt.L180M
Nucleotide_Mutation M204I
Genotype/Subtype C
Relevant Drug lamivudine (LAM)
Literature Information
PubMed PMID 18713056
Disease HBV infection
Published Year 2008
Journal The Journal of infectious diseases
Title Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus.
Author Ohkawa K,Takehara T,Kato M,Deguchi M,Kagita M,Hikita H,Sasakawa A,Kohga K,Uemura A,Sakamori R,Yamaguchi S,Miyagi T,Ishida H,Tatsumi T,Hayashi N
Evidence The G739 and T/C/A741 mutations are the causes of the rtM204V and rtM204I amino acid changes, and the occurrences of these mutations differed between viral strains with and those without rtL180M (P < .001), as described above.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation