|
Mutation Information
|
Mutation Site
|
N236T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181S;rt.N236T+rt.A181T;rt.N236T+rt.A181V |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
adefovir (ADV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
22585719
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2012 |
|
Journal
|
Journal of medical virology |
|
Title
|
Factors influencing inadequate or suboptimal response to adefovir with or without genotypic resistance. |
|
Author
|
Zhou X,Kuang X,Fan K,Zhang C,Deng G,Wang H,Wang Y |
|
Evidence
|
Seventy-six patients (47.2%) were found to carry the rtA181V/T/S or rtN236T residue substitution, and most of them had viral rebound.
|
|
|
HBV Mutation Detail Information