HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	C
Viral Reference	AB033550
Relevant Drug	tenofovir (TDF);entecavir (ETV)
Country	Japan

Literature Information

PubMed PMID	25061278
Disease	Chronic hepatitis B
Published Year	2014
Journal	Drug design, development and therapy
Title	Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir.
Author	Suzuki F,Sezaki H,Akuta N,Suzuki Y,Kawamura Y,Hosaka T,Kobayashi M,Saitoh S,Arase Y,Ikeda K,Kobayashi M,Watahiki S,Mineta R,Suzuki Y,Kumada H
Evidence	At the start of combination therapy, amino acid substitutions of the reverse transcriptase (rt) gene, rtL180M, rtT184I/M, and rtM204V, were detected.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation