|
Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.M204V+rt.L180M;rt.M204V+rt.L180M+rt.L173V |
|
Genotype/Subtype
|
A;D |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Spain |
Literature Information
|
PubMed PMID
|
17224847
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2007 |
|
Journal
|
Journal of acquired immune deficiency syndromes (1999) |
|
Title
|
Hepatitis B virus genotypes and lamivudine resistance mutations in HIV/hepatitis B virus-coinfected patients. |
|
Author
|
Ramos B,Núñez M,Martín-Carbonero L,Sheldon J,Rios P,Labarga P,Romero M,Barreiro P,García-Samaniego J,Soriano V |
|
Evidence
|
The dual L180M + M204V/I mutant was the predominant resistance pattern, although a triple rt173V + 180M + 204V, which acts as a vaccine escape mutant, was found in 1 individual.
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HBV Mutation Detail Information