HBV Mutation Detail Information

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Mutation Information

Mutation Site	A181V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	A
Relevant Drug	adefovir (ADV);lamivudine (LAM)

Literature Information

PubMed PMID	15577546
Disease	HBV-HIV coinfection
Published Year	2004
Journal	AIDS (London, England)
Title	Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment.
Author	Schildgen O,Schewe CK,Vogel M,Däumer M,Kaiser R,Weitner L,Matz B,Rockstroh JK
Evidence	Surprisingly, adefovir therapy failed, although none of the virus isolates displayed mutations known to be associated with adefovir resistance (A181V, N236T). In two isolates we identified hepatitis B virus DNA polymerase mutation L217R, in one case we found multiple frameshifts in the same region.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation