Mutation Information
Mutation Site
|
N236T |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Viral Reference
|
X70185
|
Relevant Drug
|
adefovir (ADV) |
Country
|
China |
Literature Information
PubMed PMID
|
17913933
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2007 |
Journal
|
Journal of clinical microbiology |
Title
|
Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay. |
Author
|
Libbrecht E,Doutreloigne J,Van De Velde H,Yuen MF,Lai CL,Shapiro F,Sablon E |
Evidence
|
On the basis of the LiPA results, six patients showed a transient emergence of adefovir-resistant mutants (rtA181T or rtN236T), while nine patients had adefovir-resistant mutants that persisted for several weeks, of whom eight had mutants with the rtA181T mutation.
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