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Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
entecavir (ETV) |
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Country
|
China |
Literature Information
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PubMed PMID
|
26825915
|
|
Disease
|
HBV infection
|
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Published Year
|
2016 |
|
Journal
|
Medicine |
|
Title
|
Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study. |
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Author
|
Zhang XX,Li MR,Cao Y,Zhang RW,Zhang Y,Li F,Xi HL,Xu XY |
|
Evidence
|
Fourteen patients harbored rtM204I/V substitutions of at least 1% (ranging from 1% to 3.5%), and 5 of these patients also presented rtL180 M substitutions (ranging from 1.8% to 2.6%) and rtS202G substitutions (ranging from 1% to 3.4%), which are both known to confer resistance to ETV.
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HBV Mutation Detail Information