|
Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
23114756
|
|
Clinical information
|
Yes
|
|
Disease
|
HBV infection
|
|
Published Year
|
2013 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Low-level persistence of drug resistance mutations in hepatitis B virus-infected subjects with a past history of Lamivudine treatment. |
|
Author
|
Margeridon-Thermet S,Svarovskaia ES,Babrzadeh F,Martin R,Liu TF,Pacold M,Reuman EC,Holmes SP,Borroto-Esoda K,Shafer RW |
|
Evidence
|
Sanger sequencing identified >/=1 LAM resistance mutations (rtL80I/V, rtM204I, and rtA181T) in samples from 5 (11%) of 46 LAM-experienced and none of 45 LAM-naive subjects (0%; P = 0.
|
|
|
HBV Mutation Detail Information