|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M;rt.M204V+rt.L180M;rt.M204I+rt.M204V+rt.L180M;rt.M204V+rt.L180M+rt.V173L;rt.M204V+rt.T184A+rt.L180M;rt.M204L+rt.M204I+rt.L180M;rt.T184A+rt.N238T+rt.H238T+rt.S213T+rt.M204V+rt.L180M;rt.V207M+rt.M204I+rt.L180M;rt.N236T+rt.A181T+rt.M204I+rt.L180I+rt.L180M+rt.V173L |
|
Genotype/Subtype
|
B;C |
|
Relevant Drug
|
lamivudine (LAM);telbivudine (LDT) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
26309637
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2015 |
|
Journal
|
International journal of clinical and experimental medicine |
|
Title
|
Detection and analysis of resistance mutations of hepatitis B virus. |
|
Author
|
He X,Wang F,Huang B,Chen P,Zhong L |
|
Evidence
|
Of single base mutation, L180M, M204I, M204V and V173L had higher prevalence, and the incidence of L180M was closely related to the genotype of HBV.
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|
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HBV Mutation Detail Information