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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M;rtL180M + rtM204I/V ± rtT184S/G ± rtS202I/G ± rtM250V |
|
Genotype/Subtype
|
A;B;C;D;E;F;G;H |
|
Viral Reference
|
AB241115;
AY233278;
AB116079;
AY738141;
AB194951;
AB194952;
AM180623;
AY934764;
FJ692609;
FJ692613;
GQ331047;
GQ331048;
AB014366;
D00329;
AP011084;
AY596111;
AB219427;
AP011085;
AP011086;
AP011091;
AP011093;
AP011094;
EF473977;
M54923;
AB073835;
AB115551;
AB287316;
DQ463787;
AB031265;
AB112066;
AB033553;
AB368297;
AF533983;
HQ622095;
KU695745;
KU695746;
X75656;
X75665;
AB048704;
AB048705;
KF873543;
KF873545;
AB241109;
AP011099;
EU410081;
KM999992;
KM999993;
AP011103;
AP011102;
EU670263;
AP011104;
AP011105;
AP011106;
AP011107;
AP011108;
AB540583;
AB554019;
AB554020;
AB554018;
AB554025;
AB644280;
AB644281;
GQ377555;
HM011493;
AB644286;
AB644287;
FJ904424;
X80926;
AB109475;
Z35716;
AB493845;
AB493846;
AY233291;
X65257;
AB033559;
AB048702;
AB033558;
DQ315779;
AM494716;
FJ904430;
AB091256;
HM363610;
X75664;
AY090459;
DQ823095;
HM585194;
AY090455;
DQ899143;
X69798;
AB036905;
AB036915;
MH051986;
AB166850;
DQ823090;
KJ843175;
AB056513;
AB064310;
EF634480;
AB516395;
AY090454;
AY090457;
FJ023664;
FJ023660;
AB486012 |
|
Relevant Drug
|
telbivudine (LDT);entecavir (ETV) |
|
Country
|
Australia;Caribbean;Central America;Central Asia;Eastern Africa;Eastern Asia;Eastern Europe;Melanesia;Middle Africa;Northern Africa;North America;Northern Europe;Polynesia;South America;South-eastern Asia;Southern Africa;Southern Asia;Southern Europe;Western Africa;Western Asia;Western Europe;New Zealand. |
Literature Information
|
PubMed PMID
|
33381105
|
|
Disease
|
Hepatocellular carcinoma
|
|
Published Year
|
2020 |
|
Journal
|
Frontiers in microbiology |
|
Title
|
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region. |
|
Author
|
Araujo NM,Teles SA,Spitz N |
|
Evidence
|
Overall, rtL180M, rtA181T/V, rtT184G/S, rtS202G/I, rtM204I, rtM204V, rtN236T, and rtM250V were more frequently detected in genotypes A (13.9%), C (0.8%), D (0.1%), H (3.8%), G (25%), A (13.1%), B (0.7%), and C (0.1%), respectively.
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HBV Mutation Detail Information