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Mutation Information
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Mutation Site
|
I233V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
adefovir (ADV) |
Literature Information
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PubMed PMID
|
22505793
|
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Published Year
|
2011 |
|
Journal
|
International journal of current chemistry |
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Title
|
Hepatitis B Virus genotypic differences map structurally close to NRTI resistance hot spots. |
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Author
|
Michailidis E,Singh K,Kirby KA,Hachiya A,Yoo W,Hong SP,Kim SO,Folk WR,Sarafianos SG |
|
Evidence
|
The drug resistance mutations V84M and S85A cause ADV resistance and are close to residues 237 and 238 that vary among different genotypes and also proximal to the I233V ADV-resistance position, which is close to residue 91 that varies among different genotypes (233 and 91 are in cluster II).
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HBV Mutation Detail Information