HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204V+rt.L180M

Literature Information

PubMed PMID	17692425
Disease	Chronic hepatitis B
Published Year	2007
Journal	Journal of hepatology
Title	Pooled analysis of amino acid changes in the HBV polymerase in patients from four major adefovir dipivoxil clinical trials.
Author	Borroto-Esoda K,Miller MD,Arterburn S
Evidence	An additional 3 patients had mutations at other strictly conserved sites without the rtA181V and/or rtN236T mutations; one patient in study GS-98-435 had a switch in HBV genotype from C to B which resulted in the appearance of numerous polymorphic changes and a conserved site mutation at rtV208I, one patient in study GS-96-412 developed the double mutation rtL180M + rtM204V possibly due to undocumented use of lamivudine in the clinical study and one patient in study GS-98-438 developed the rtS185T + rtY327S mutations.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation