HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204I+rt.L180M;rt.M204S+rt.L180M;rt.M204V+rt.L180M;rt.M204V+rt.L180M+rt.V173L;rt.M204V+rt.T184L+rt.L180M;rt.M250L+rt.M204V+rt.L180M;rt.M204V+rt.S202G+rt.L180M
Relevant Drug	lamivudine (LAM)
Country	China

Literature Information

PubMed PMID	28300730
Disease	Chronic hepatitis B
Published Year	2017
Journal	Antiviral therapy
Title	The enrichment of HBV immune-escape mutations during nucleoside/nucleotide analogue therapy.
Author	Shan M,Shen Z,Sun H,Zheng J,Zhang M
Evidence	The double (rtV173L+rtM204I) and triple (rtV173L/T184L+rtL180M+rtM204V) mutations not only conferred resistance to LMV, but also resulted in two mutations in S protein.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation