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Mutation Information
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Mutation Site
|
S223A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.S223A+s.G145R;rt.S223A+s.W196L+rt.M204V |
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Relevant Drug
|
lamivudine (LAM) |
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Country
|
China |
Literature Information
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PubMed PMID
|
16830379
|
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Disease
|
Chronic hepatitis B
|
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Published Year
|
2006 |
|
Journal
|
World journal of gastroenterology |
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Title
|
Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs. |
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Author
|
Lu HY,Zeng Z,Xu XY,Zhang NL,Yu M,Gong WB |
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Evidence
|
Because the S gene overlaps with the major calatytic domain of the polymerase gene, the mutations near the YMDD motif of the polymerase gene were studied. Eight mutations within amino acid residues 518-569 of the polymerase gene were observed at 4 positions (V173L, L180M, M204I/V, S223A) in 5 patients.
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HBV Mutation Detail Information