|
Mutation Information
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Mutation Site
|
M204S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
12823591
|
|
Clinical information
|
Yes
|
|
Disease
|
HBV infection
|
|
Published Year
|
2003 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine. |
|
Author
|
Bozdayi AM,Uzunalimoğlu O,Türkyilmaz AR,Aslan N,Sezgin O,Sahin T,Bozdayi G,Cinar K,Pai SB,Pai R,Bozkaya H,Karayalçin S,Yurdaydin C,Schinazi RF |
|
Evidence
|
In conclusion, the results indicate that, in addition to a Met --> Val and Met --> Ile change in YMDD, a Met --> Ser change at rt204 (YMDD --> YSDD) associated with the rtL180M change can also emerge during lamivudine treatment, which confers lamivudine resistance in vivo and in vitro, leading to virological breakthrough and ALT increases.
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HBV Mutation Detail Information