|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L229V;rt.M204I+rt.L229F |
|
Amino acid_Mutation
|
G741T/A |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV);telbivudine (LDT) |
|
Country
|
china |
Literature Information
|
PubMed PMID
|
33124952
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2020 |
|
Journal
|
Emerging microbes & infections |
|
Title
|
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients. |
|
Author
|
Fu Y,Wu S,Hu Y,Chen T,Zeng Y,Liu C,Ou Q |
|
Evidence
|
Putative resistance mutations were observed at 8 AA sites among the panel of treatment-naive patients; they were rtV191I, rtS213T, rtV214A, rtE218D, rtL229V, rtI233V, rtN238S, rtS/C256G. The classical NA-r mutations rtL180M (ntT/C667A) and rtM204V/I (ntA739G or ntG741T/A), were treatment-specific and were preferentially present in post-treatment patients.
|
|
|
HBV Mutation Detail Information