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Mutation Information
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Mutation Site
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M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.L180M+rt.M204V;rt.T184S+rt.T184A+rt.M204V;rt.V173L+rt.M204V |
|
Genotype/Subtype
|
A;D |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Italy+other countries |
Literature Information
|
PubMed PMID
|
19041149
|
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Disease
|
HBV infection
|
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Published Year
|
2009 |
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Journal
|
Journal of hepatology |
|
Title
|
The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes. |
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Author
|
Svicher V,Gori C,Trignetti M,Visca M,Micheli V,Bernassola M,Salpini R,Gubertini G,Longo R,Niero F,Ceccherini-Silberstein F,De Sanctis GM,Spanò A,Cappiello G,Perno CF |
|
Evidence
|
In genotype A, the rtM204V (prevalence: 68.2%) was the main sign of lamivudine failure. Multivariate analysis confirmed that genotype A is the only predictor for rtM204V emergence (OR: 14.5 [95% CI: 1.3-158], P=0.02).
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HBV Mutation Detail Information