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Mutation Information
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Mutation Site
|
Q215S |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
|
D |
|
Relevant Drug
|
adefovir (ADV) |
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Country
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Iran |
Literature Information
|
PubMed PMID
|
23596461
|
|
Disease
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Hepatocellular carcinoma;
Chronic hepatitis B;
Liver cirrhosis;
Acute hepatitis B;
Fulminant hepatitis B
|
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Published Year
|
2013 |
|
Journal
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Hepatitis monthly |
|
Title
|
Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naïve chronic HBV patients. |
|
Author
|
Mahabadi M,Norouzi M,Alavian SM,Samimirad K,Azad TM,Saberfar E,Mahmoodi M,Ramezani F,Karimzadeh H,Malekzadeh R,Montazeri G,Nejatizadeh A,Ziaee M,Abedi F,Ataei B,Yaran M,Sayad B,Hossein Somi M,Sarizadeh G,Sanei-Moghaddam I,Mansour-Ghanaei F,Rafatpanah H,Pourhosseingholi MA,Keyvani H,Kalantari E,Saberifiroozi M,Ali Judaki M,Ghamari S,Daram M,Fazeli Z,Goodarzi Z,Khedive A,Moradi A,Jazayeri SM |
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Evidence
|
RT sequence changes implicated in adefovir-resistance were detected, including S213T 5.83% (19/325), S213N 0.9% (3/325), V214E 0.61% (2/325), V214A 0.61% (2/325), Q215P 2.75% (9/325), Q215S 7.06% (23/325), Q215H1.53% (5/325), and F221Y 2.76% (9/325) of isolations that previously reported adefovir-resistance mutation (Figure 1).
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HBV Mutation Detail Information