|
Mutation Information
|
Mutation Site
|
A181V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
19301976
|
|
Disease
|
Chronic hepatitis B;
HBV-HIV coinfection
|
|
Published Year
|
2009 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients. |
|
Author
|
Margeridon-Thermet S,Shulman NS,Ahmed A,Shahriar R,Liu T,Wang C,Holmes SP,Babrzadeh F,Gharizadeh B,Hanczaruk B,Simen BB,Egholm M,Shafer RW |
|
Evidence
|
The direct PCR sequences were dominated by 3TC-resistance mutations: L180M and M204V/I in 9 samples; V173L, L180M, and M204V in 5 samples; L180M, A181V (a mutation associated with ADV and 3TC resistance), and M204V in 1 sample; and V173L alone in 1 sample.
|
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HBV Mutation Detail Information