|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Viral Reference
|
X02763.1
|
|
Country
|
China |
Literature Information
|
PubMed PMID
|
24348637
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2013 |
|
Journal
|
Hepatitis monthly |
|
Title
|
Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance. |
|
Author
|
Qin B,Zhang B,Zhang X,He T,Xu W,Fu L,Tu C |
|
Evidence
|
The results indicated that rtL180M and/or rtM204V/I and/or rtQ267H had no influence on HBsAg and HBeAg expression comparing to that of WT HBV, in spite of the fact that rtM204V and rtM204I led to sI195M and sW196S in S ORF, due to overlapping between S and P gene (20).
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HBV Mutation Detail Information