HBV Mutation Detail Information

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Mutation Information

Mutation Site	M204V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204V+rt.L180M+rt.A194T;rt.M204V+rt.A194T+rt.L180M;rt.M204V+rt.L180M
Relevant Drug	tenofovir (TDF);lamivudine (LAM)

Literature Information

PubMed PMID	21860069
Published Year	2011
Journal	Antiviral chemistry & chemotherapy
Title	The YMDD and rtA194T mutations result in decreased replication capacity in wild-type HBV as well as in HBV with precore and basal core promoter mutations.
Author	Zhu Y,Curtis M,Borroto-Esoda K
Evidence	BACKGROUND: A recent study indicated that addition of the hepatitis B e antigen (HBeAg) precore (PC) or basal core promoter (BCP) mutations to wild-type HBV offset the reduced replication of the HBV polymerase rtA194T+/-rtL180M+rtM204V mutations.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation