|
Mutation Information
|
Mutation Site
|
L129M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Viral Reference
|
GQ872210.1
|
|
Relevant Drug
|
clevudine (CLV);lamivudine (LAM) |
|
Country
|
korea |
Literature Information
|
PubMed PMID
|
20164224
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2010 |
|
Journal
|
Journal of virology |
|
Title
|
Identification and characterization of clevudine-resistant mutants of hepatitis B virus isolated from chronic hepatitis B patients. |
|
Author
|
Kwon SY,Park YK,Ahn SH,Cho ES,Choe WH,Lee CH,Kim BK,Ko SY,Choi HS,Park ES,Shin GC,Kim KH |
|
Evidence
|
A quadruple mutant (L129M, V173L, M204I, and H337N) was identified that conferred greater replicative ability and strong resistance to both CLV and lamivudine.
|
|
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HBV Mutation Detail Information