Mutation Information
Mutation Site
|
V173L |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.V173L+rt.L180M+rt.L80V;rt.V173L+rt.L180M+rt.L80I |
Literature Information
PubMed PMID
|
21831732
|
Disease
|
HBV infection
|
Published Year
|
2011 |
Journal
|
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver |
Title
|
Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development. |
Author
|
Svicher V,Cento V,Salpini R,Mercurio F,Fraune M,Beggel B,Han Y,Gori C,Wittkop L,Bertoli A,Micheli V,Gubertini G,Longo R,Romano S,Visca M,Gallinaro V,Marino N,Mazzotta F,De Sanctis GM,Fleury H,Trimoulet P,Angelico M,Cappiello G,Zhang XX,Verheyen J,Ceccherini-Silberstein F,Perno CF |
Evidence
|
Highest genetic barrier is found for secondary/compensatory mutations (e.g. rtL80I/V-rtL180M-rtV173L), whilst most primary mutations (including rtM204V-rtA181T/V-rtI169T-rtA194T) are associated with low genetic barrier.
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