HBV Mutation Detail Information

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Mutation Information

Mutation Site	A194T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	tenofovir (TDF)
Country	Korea

Literature Information

PubMed PMID	19578241
Disease	Chronic hepatitis B
Published Year	2009
Journal	Antiviral therapy
Title	Adefovir dipivoxil resistance patterns in patients with lamivudine-resistant chronic hepatitis B.
Author	Santantonio T,Fasano M,Durantel S,Barraud L,Heichen M,Guastadisegni A,Pastore G,Zoulim F
Evidence	Moreover, among patients without virological breakthrough, amino acid substittions at positions 184 and 250 (rtT184S/A and rtM250L) potentially associated with resistance to entecavir, and the controversial rtA194T mutation associated with resistance to tenofovir, were found in seven and one patients, respectively, who were treated with 3TC for a median period of 38 months (Figure 1).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation