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Mutation Information
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Mutation Site
|
M204V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
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PubMed PMID
|
20169198
|
|
Published Year
|
2010 |
|
Journal
|
PloS one |
|
Title
|
Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir. |
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Author
|
Walsh AW,Langley DR,Colonno RJ,Tenney DJ |
|
Evidence
|
Changes in the HBV polymerase reverse-transcriptase (RT) domain involve lamivudine-resistance (LVDr) substitutions in the conserved YMDD motif (M204V/I +- L180M), plus an additional ETV-specific change at residues T184, S202 or M250.
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HBV Mutation Detail Information