HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Viral Reference	EU871982.1
Country	China

Literature Information

PubMed PMID	24788140
Disease	Hepatocellular carcinoma
Published Year	2014
Journal	PloS one
Title	Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Author	Wu Y,Gan Y,Gao F,Zhao Z,Jin Y,Zhu Y,Sun Z,Wu H,Chen T,Wang J,Sun Y,Fan C,Xiang Y,Qian G,Groopman JD,Gu J,Tu H
Evidence	It is worth noting that we did not observe any of the common NA-related resistance mutations including rtM204V/I, rtS202C/G/I, rtL180M, rtA181T/V, rtT184A/I/L/G/C/M, rtA194T, rtI169T, rtV173L, rtL80I, rtN236T, and rtM250I/V [12], [13], [24], suggesting that these variants were either absent or present at a very low frequency in our study subjects.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation