HBV Mutation Detail Information

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Mutation Information
Mutation Site M204I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.M204I+rt.L180M
Amino acid_Mutation G741T/C/A
Genotype/Subtype C
Viral Reference X01587
Relevant Drug lamivudine (LAM)
Literature Information
PubMed PMID 18713056
Disease HBV infection
Published Year 2008
Journal The Journal of infectious diseases
Title Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus.
Author Ohkawa K,Takehara T,Kato M,Deguchi M,Kagita M,Hikita H,Sasakawa A,Kohga K,Uemura A,Sakamori R,Yamaguchi S,Miyagi T,Ishida H,Tatsumi T,Hayashi N
Evidence BACKGROUND: Hepatitis B virus (HBV) establishes lamivudine resistance via the resistance-causative rtM204V/I mutation and the replication-compensatory rtL180M mutation.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation