|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
14557667
|
|
Disease
|
HBV infection
|
|
Published Year
|
2003 |
|
Journal
|
Journal of virology |
|
Title
|
The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. |
|
Author
|
Delaney WE 4th,Yang H,Westland CE,Das K,Arnold E,Gibbs CS,Miller MD,Xiong S |
|
Evidence
|
Genotypic changes in the YMDD motif (reverse transcriptase [rt] mutations rtM204V/I) conferred resistance to lamivudine as well as reducing the in vitro replication efficiency of HBV.
|
|
|
HBV Mutation Detail Information