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Mutation Information
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Mutation Site
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S135Y |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Viral Reference
|
HM358335.1
|
|
Country
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Iran |
Literature Information
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PubMed PMID
|
27381922
|
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Clinical information
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Yes
|
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Disease
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HBV-HIV coinfection
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Published Year
|
2017 |
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Journal
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Journal of medical virology |
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Title
|
HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg. |
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Author
|
Sadeghi A,Shirvani-Dastgerdi E,Tacke F,Yagmur E,Poortahmasebi V,Poorebrahim M,Mohraz M,Hajabdolbaghi M,Rasoolinejad M,Abbasian L,Jafari R,Fakhari Z,Norouzi M,Ebrahimian A,Geravand B,Alavian SM,Jazayeri SM |
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Evidence
|
The sP127L and sP127T + sS136Y mutations led to rtH124N and rtS135Y substitutions (rt refers to reverse transcriptase), which are located in pol/rt A‐B functional inter domain. No mutations were found in YMDD motif.
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HBV Mutation Detail Information