HBV Mutation Detail Information

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Mutation Information

Mutation Site	S202I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	entecavir (ETV)
Country	Japan

Literature Information

PubMed PMID	25817219
Disease	Chronic hepatitis B
Published Year	2015
Journal	Journal of hepatology
Title	Characterization of novel entecavir resistance mutations.
Author	Hayashi S,Murakami S,Omagari K,Matsui T,Iio E,Isogawa M,Watanabe T,Karino Y,Tanaka Y
Evidence	In contrast, clone A186T/LAMr replicated at a moderately decreased level compared with C_JPNAT (43.4%), suggesting that mutation rtA186T, but not I163V, decreases replication efficacy, similar to the previously reported ETV resistance mutations rtS202G, rtS202I, and rtT184G

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation