Mutation Information
Mutation Site
|
H238Q |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Country
|
China |
Literature Information
PubMed PMID
|
31189581
|
Disease
|
HBV associated liver disease;
Chronic hepatitis B
|
Published Year
|
2019 |
Journal
|
Journal of clinical microbiology |
Title
|
Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing. |
Author
|
Fu Y,Zeng Y,Chen T,Chen H,Lin N,Lin J,Liu X,Huang E,Wu S,Wu S,Xu S,Wang L,Ou Q |
Evidence
|
Notably, 3 putative NAr mutations (rtL229V, H238Q, and S/C256G) with rates between 20% and 25% tested by NGS in patients 3, 20, and 497, respectively, were not detected by Sanger sequecing, implying the limitation of Sanger sequencing further.
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