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Mutation Information
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Mutation Site
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M204V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.V173L+rt.L180M+rt.M204I+rt.M204V |
|
Viral Reference
|
X70185
|
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV);adefovir dipivoxil (ADV) |
|
Country
|
China |
Literature Information
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PubMed PMID
|
17913933
|
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Disease
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Chronic hepatitis B
|
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Published Year
|
2007 |
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Journal
|
Journal of clinical microbiology |
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Title
|
Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay. |
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Author
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Libbrecht E,Doutreloigne J,Van De Velde H,Yuen MF,Lai CL,Shapiro F,Sablon E |
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Evidence
|
In all 20 patients, the mutation occurred in the YMDD motif at reverse transcriptase position 204 (rt204; M204V/I) either with or without the compensatory mutation at position rt180 (L180M). A compensatory mutation at position rt80 (L80V/I) was detected in half of these patients. After 36 months, a compensatory mutation was seen at position rt173 (V173L) in 3/15 patients.
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HBV Mutation Detail Information