HBV Mutation Detail Information

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Mutation Information

Mutation Site	I53V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	A
Relevant Drug	adefovir (ADV)
Country	Italy

Literature Information

PubMed PMID	23026293
Disease	Chronic hepatitis B
Published Year	2012
Journal	Antiviral research
Title	Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy.
Author	Mirandola S,Sebastiani G,Rossi C,Velo E,Erne EM,Vario A,Tempesta D,Romualdi C,Campagnolo D,Alberti A
Evidence	Comparison with sequencing data of patients failing LMV or LAM+ADV therapy revealed an higher frequency of novel genotype-specific mutations if compared with naive patients: 3 mutations under LAM monotherapy in HBV-D (rtS85F; rtL91I; rtC256G) and 3 mutations under ADV therapy in HBV-A (rtI53V; rtW153R; rtF221Y).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation