|
Mutation Information
|
Mutation Site
|
A181V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.180M+rt.A181V+rt.T184A+rt.S202G+rt.M204V |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
entecavir;lamivudine;adefovir |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
33571155
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2021 |
|
Journal
|
Journal of infection in developing countries |
|
Title
|
Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients. |
|
Author
|
Shao J,Liu Y,Liu LM,Chen R,Zhao L,Zhou Y,Li L,Li X,Li J,Xu D |
|
Evidence
|
RESULTS: ETV-resistant mutants were continuously detected in 10 of the 12 patients, and multidrug-resistant (MDR) mutants, including a novel strain (rtL180M+A181V+T184A+S202G+M204V), were detected in two patients.
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HBV Mutation Detail Information