Mutation Information
Mutation Site
|
V173L |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Relevant Drug
|
lamivudine (LAM) |
Country
|
Japan |
Literature Information
PubMed PMID
|
25817219
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2015 |
Journal
|
Journal of hepatology |
Title
|
Characterization of novel entecavir resistance mutations. |
Author
|
Hayashi S,Murakami S,Omagari K,Matsui T,Iio E,Isogawa M,Watanabe T,Karino Y,Tanaka Y |
Evidence
|
The analysis also identified multiple mutations in the reverse transcriptase (RT) that occurred before and after ETV treatment. At baseline (0 month), when the patient was refractory to LAM treatment, serum HBV contained the well-documented LAM resistance mutations rtV173L, rtL180M, and rtM204I
|
|
|