|
Mutation Information
|
Mutation Site
|
M250V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M250V+rt.L180M+rt.M204V |
|
Relevant Drug
|
entecavir (ETV) |
Literature Information
|
PubMed PMID
|
18435459
|
|
Disease
|
HBV infection
|
|
Published Year
|
2008 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance. |
|
Author
|
Baldick CJ,Tenney DJ,Mazzucco CE,Eggers BJ,Rose RE,Pokornowski KA,Yu CF,Colonno RJ |
|
Evidence
|
Other resistant substitutions included rtL80V/I, rtT184S, and rtA200V, and combined mutation of triple resistant substitutions was detected in HBV RT region of 5 patients by direct sequencing.
|
|
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HBV Mutation Detail Information