HBV Mutation Detail Information

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Mutation Information

Mutation Site	A181V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	D
Relevant Drug	adefovir (ADV)
Country	Germany

Literature Information

PubMed PMID	22892524
Disease	HBV infection
Published Year	2012
Journal	Antiviral therapy
Title	Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy.
Author	van Bömmel F,Trojan J,Deterding K,Wedemeyer H,Wasmuth HE,Hüppe D,Möller B,Bock FJ,Feucht HH,Berg T
Evidence	To assess the clinical relevance of this cross-resistance, we studied the evolution of HBV polymerase gene variants in patients with genotypic resistance against ADV (rtN236T and/or rtA181V/T) during TDF treatment.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation