Mutation Information
Mutation Site
|
M204I |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Country
|
China |
Literature Information
PubMed PMID
|
21149924
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2010 |
Journal
|
Antiviral therapy |
Title
|
Profile of HBV antiviral resistance mutations with distinct evolutionary pathways against nucleoside/nucleotide analogue treatment among Chinese chronic hepatitis B patients. |
Author
|
Yang JX,Liu BM,Li XG,Yan CH,Xu J,Sun XW,Wang YH,Jiao XJ,Yan L,Dong JP,Hou CS,Abuduheilili X,Li T,Zhuang H |
Evidence
|
RtM204 mutations (27 rtM204I, 15 rtM204V and 5 rtM204I/V cases) were detected at the highest frequency among 65 mutants (72.30% [47/65]) and found to display 16 combination mutation patterns, in which rtM204I and rtM204V were significantly associated with rtL80I/V and rtL180M, respectively (P<0.01).
|
|
|