|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.L180M+rt.M204V+rt.I233V;rt.V173L+rt.L180M+rt.M204V+rt.M204I+rt.I233V |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
26079809
|
|
Disease
|
HBV infection
|
|
Published Year
|
2016 |
|
Journal
|
Antiviral therapy |
|
Title
|
Increased occurrence of mutant rtI233V of HBV in patients receiving adefovir therapy. |
|
Author
|
Liu Y,Xin S,Ye X,Chen R,Xu Z,Li X,Ye H,Cheng S,Xu D |
|
Evidence
|
Direct sequencing showed that rtI233V substitution emerged alone in 33 patients, in conjunction with LAM-resistant mutation (rtA181V, rtN236T) in 9 patients, and in conjunction with LAM-resistant mutation (rtM204I, rtM204V) in 4 patients who had experienced LAM prior to ADV treat-ment (Table 1).
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HBV Mutation Detail Information